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The FloMeD study demonstrates the role highly-bioavailable curcumin plays in increasing FMD suggesting curcumins cardioprotective effects may stem from its ability to mitigate oxidative stress and inflammation while increasing expression of antioxidant enzymes. Cardiovascular disease, the leading cause of death globally, begins with impaired endothelial function. This new research offers a potential strategy for early prevention and associated costs of CVD as well new opportunities for healthy aging and performance and recovery in sports nutrition.