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Plant sterols/stanols are known to inhibit fractional intestinal cholesterol absorption, which translates in significant LDL-C reductions up to 12%. Novel interesting aspects of plant sterols/stanols relate to effects beyond lowering serum LDL-C. First, plant sterols and stanols lower serum TAG concentrations and they influence the functioning of our immune system via a changed activity of the regulatory T-cells. This combination of effects makes these compounds highly attractive to decrease CVD risk, however it also suggests that other patient groups might benefit from these novel effects. Plant sterols and stanols inhibit fractional intestinal cholesterol absorption, which translates in significant LDL-C reductions up to 12%, independent of background diets and the use of cholesterol-lowering drugs.