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Gut microbiota dysbiosis can impair bile acid metabolism and is associated with metabolic disease. There is significant potential for developing probiotic treatments that impact bile acid metabolism, and support heart health, through the microbiota. Our group has demonstrated that supplementation with bile salt hydrolase active LRC can significantly benefit lipid and inflammatory profiles while supporting gut health. We will present the development of this unique probiotic , results of randomized controlled trials and expectations going forward.