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The growing epidemic of overweight and obesity is increasingly becoming a major challenge to the health providers across the globe. Treatment options are limited by availability, tolerability and side effects. Bariatric surgery is today the only effective way of maintaining long-term weight loss in mammals. Encapsulation of macronutrients represents a revolutionary technology capable of treating obesity by mimicing gastric bypass and subsequently reducing appetite by local exposure of macronutrient to distal part of small bowel.