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Eggshell membrane (ESM) is known to reduce the expression of various pro-inflammatory cytokines, including the key mediators of inflammation interleukin-1beta (IL-1b) and tumor necrosis factor-alpha (TNF-a) both in vitro and in vivo. NEM, has demonstrated safety and efficacy in multiple clinical trials in relieving joint pain and stiffness in humans with OA (Osteoarthritis) and has been shown to reduce CTX-II levels in a healthy population demonstrating a substantial chondro-protective effect.